This August (2025), the U.S. Food & Drug Administration (FDA) set out draft guidance that could significantly impact the future of clinical trials focused on oncology treatments. Building on recent cross-industry discussions around endpoints, the 18 page document details several … Read More
clinical trials
Converging on the continuous: How drug exposure and patient outcomes are aligning in a data-rich future for clinical trials
So strong is the human allegiance to the status quo that it is rare for the momentum of change not to be accompanied by frictional forces of resistance. Rather than running towards new ways of working, our natural instinct typically … Read More
MEMS AS®: The Foundation of Digital Patient Adherence Monitoring in Clinical Trials
What Is Patient Adherence and Why It Matters According to the World Health Organization (WHO), “adherence to long-term therapies is the extent to which a person’s behavior, taking medication, following a diet, and executing lifestyle changes corresponds with agreed recommendations … Read More
The Practice-Protocol Paradox: Exploring problematic assumptions around medication adherence in clinical trials
Understanding the Practice-Protocol Paradox in Medication Adherence As humans, the unconscious act of making assumptions is inherent in our DNA. These mental shortcuts are deeply wired into our brains as a way of quickly making sense of the world around … Read More
Flawed dosing and forgiveness failings in the battle against adherence errors
The perfectionists among us might outwardly disagree, but, in truth, even they would secretly admit that it is not possible to live a life free from mistakes. We are complex beings living and working in complex environments and, therefore, we … Read More
Electronic monitoring in clinical trials: a guide for sponsors and CROs
Clinical trials rely on accurate data. But what if one of the most important variables whether a patient actually takes the medication is based on guesswork? Traditional methods like pill counts, diaries, or verbal confirmation have long been the standard, … Read More
How poor adherence skews clinical trial results and what to do about it
Imagine spending years developing a promising new treatment, only to have its potential clouded by something as simple (and as overlooked) as whether or not people actually took their pills. This isn’t just a small glitch in the process. In … Read More
Medication adherence VS compliance: what’s the difference and why it matters
You’ll often hear the terms “adherence” and “compliance” used as if they mean the same thing. But in healthcare and clinical research, they carry very different meanings. Understanding that difference can change the way we work with patients, design better … Read More
AARDEX Group and Pill Connect Partner to Advance Dose Selection with Real-Time Adherence Monitoring in Phase 2A Clinical TrialÂ
Liège, Belgium and Manchester, UK; August 2025: AARDEX Group, a global leader in digital medication adherence solutions, and Pill Connect, a pioneer in connected dispensing technology, have announced a strategic partnership to support a multi-cohort Phase 2A dose selection trial. … Read More
What is medication adherence and why does it matter in clinical trials?
Medication adherence is an element of successful clinical research. It refers to the degree to which a patient follows a prescribed medication regimen including when and how often the medication is taken, and whether it is discontinued prematurely. In clinical … Read More